Morphometric Features of Membranous Glomerulonephritis with Nephrotic Syndrome and Correlation of Morphological and Laboratory Indicators


  • Allaberdiev B. T. Tashkent State Dental Institute



nephrotic syndrome, morphological form of glomerulonephritis


The results of biopsies obtained from patients with nephrotic syndrome were studied. Necessary material for research was collected from patients, who were on treatment and nephrological department of the 1st polyclinic MZ RUz. A comprehensive clinical and laboratory examination was performed in 104 patients. Of these, 58 had a proteinuric form of chronic glomerulonephritis. The mean age of the patients was 24.9±5.2 years. Depending on the morphological variant of glomerulonephritis, all patients were divided into 5 groups. The data of the correlation analysis of the studied morphometric parameters and the data of routine laboratory studies made it possible to create a mathematical model that can be used to determine the morphological form of chronic glomerulonephritis.


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West G.D. Childhood membranoproliferative glomerulonefritis: An approach to management.// Kidney Int.-1986..-Vol. 29 № 8.-P. 1077-1093.

Schmit H., Bohle A. Tubulointerstitial alternations in type I membranoproliferative glomerulonephritis. An investigation of 259 cases.// Path. Res. Pract. 1987.-Vol.182, №1-P.6-10.

Peruzzi L., et al. Tubulointerstitial responses in the рrogression of glomerular disseases: albuminuria modulates alpha-beta 5 integrin. Kidney Int. 1996 Oct; 50(4)1310-20.

Mactier R., et al. The natural History of embranous nephropathy in the west skotland.// Quart J. Med., New Sep.-1981.-Vol.60, № 232.-P.946-956.

Honkanen E. et al. Membranous glomerulonephritis in rheumatoid arthritis not related to goldor d-penicilamine therapy: a report of four cases and review of the literature.//Clin. Nephrol. -1986.-Vol.18. № 2.-P. 87-93.

Zucchelli P., Cagnoli L., Pasquali S et al. Clinical and morphologic evolution idiopathic membranous efropathy.// Clin Nephrol.- 1986.- Vol. 25.

Beck LH, Bonegio RG, Lambeau G. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 361(1):11, 2009. doi: 10.1056/NEJMoa0810457

Fervenza FC, Appel GB, BarbourSJ, et al: Rituximab or cyclosporine in the treatment of membranous nephropathy. N Engl J Med 381(1):36-46, 2019. doi: 10.1056/NEJMoa1814427

Ronco P, Debiec H. Molecular pathogenesis of membranous nephropathy. Annu Rev Pathol Mech Dis. 2020. 15:287–313 2.

Alsharhan L, Beck LH. Membranous Nephropathy: Core Curriculum 2021. Am J Kidne Dis. 2020; XX(XX):1-14. doi:10.1053/j.ajkd.2020.10.009 3.

Xu Z, Chen L, Xiang H et al. Advances in Pathogenesis of Idiopathic Membranous Nephropathy. Kidney Dis. 2020 Sep 6(5): 330-345. doi: 10.1159/00050770

Ganieva, Z. B., Reynazarova, G. D., Fayzieva, Z. T., & Usmanova, Z. U. (2021). EXPERIMENTAL STUDY OF THE CHRONIC TOXICITY OF THE TRIBULEPIL COLLECTION. World Bulletin of Public Health, 4, 11-19.




How to Cite

B. T., A. . (2022). Morphometric Features of Membranous Glomerulonephritis with Nephrotic Syndrome and Correlation of Morphological and Laboratory Indicators. INTERNATIONAL JOURNAL OF HEALTH SYSTEMS AND MEDICAL SCIENCES, 1(6), 108–111.