Prevalence of Extended Spectrum Beta Lactamase Producing Klebsiella Pneumoniae in Urine Samples From Patients Attending Benue State University Teaching Hospital, Makurdi

Abstract

Klebsiella pneumoniae is one of the most predominant pathogens commonly isolated in urine. This uropathogen has developed resistance to antibiotics over the years and is increasingly becoming a public health problem. The aim of this study was to determine the prevalence of extended spectrum producing Klebsiella pneumoniae from clinical isolates obtained from Benue State University Teaching Hospital Makurdi.50 clinical urine isolates were obtained from in-patients from the study area and analysed for the presence of extended spectrum K. pneumoniae using standard diagnostic procedures. There were more ESBL positive cases (60.0%) than ESBL negative cases (40.0%) in this study. There was no statistically significant relationship between ESBL producing K. pneumoniae and Age (χ²=1.857; DF=3;p=0.395); and ESBL cases and sex (χ²=2.130; df=1;P=0.144). All the risk factors including difficulty in urination, Painful urination, Unpleasant urination, Use of catheter to aid urination, Frequent urination, Duration of admission in the hospital, Use of antibiotics for treatment, and use of antibiotics in the last 3 months (P>0.05) were not statistically related to K. pneumoniae infection in the study. Isolates such as K. pneumoniae, P. aeruginosa, P. mirabilis, E. coli, and P. vulgaris were identified from the urine samples using biochemical tests. Patients exhibiting symptoms and those without symptoms should be screened for the presence of ESBL producing K. pneumonia.