Circular RNAs in Tumor Therapy
Keywords:
RNA, circRNAs, miRNAAbstract
Contrary to the common belief that circRNAs are "mistakes" in RNA splicing, mammalian cells really contain a large number of highly conserved circRNAs. CircRNAs may produce miRNA inhibitors that are stable and potent. Nevertheless, many questions regarding the role of circRNAs remain to be resolved. First off, circular RNAs have the same ability to stop the spread of cancer as long noncoding RNAs. Circular RNAs (circRNAs) are a subclass of non-coding RNAs that lack poly (A) tails on either the 3′or 5′ends. Over 100,000 genes are known to encode circRNAs. Clinical data indicates that circRNAs, which exhibit variable expression in several disorders, including cancer, may serve a regulatory role in some conditions and diseases. Recent studies demonstrate that As an endogenous competitive RNA, circRNA can control the invasion, growth, and other physiological functions of tumor cells. Additionally, some circRNAs located in the nucleus can regulate the translation of the parent gene by binding to RNA polymerase II.
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