Liver Function Test among Patients with Non-Alcoholic Fatty Liver Disease
Keywords:
Non-alcoholic fatty liver disease, aspartate aminotransferase, Alanine transaminase, Total Serum BilirubinAbstract
NAFLD is one of the most common liver diseases worldwide, and is associated with obesity, type 2 diabetes, high blood pressure, and body fat imbalance. The disease is classified into two main types: simple fatty liver, which does not usually lead to liver damage, and non-alcoholic steatohepatitis (NASH), which can progress to scarring (fibrosis) of the liver or even liver failure. The effect of non-alcoholic fatty liver disease on liver function levels and the relationship between them. The study included 75 patients with NAFLD, 34 males and 41 females, 18-75 years of age, they are diagnosed by ultrasound at GIT & hepatobiliary, and other group as control group included 81 apparently healthy subjucts 46 males and 35 females, 18-75 years of age. Physiological measurements include waist circumference, height, weight, BP, Approximately 5 ml of venous blood samples were obtained from both control individuals and patients with NAFLD after 10-12 hour overnight fasting by using sterile disposable syringes for the assessment of total serum bilirubin, unconjugated and conjugated bilirubin, Aspartate aminotransferase (AST), and alanine aminotransferase (ALT). The results shows a significant increase in the levels of AST and ALT (P<0.01) in patients group, while there is non-significant change (P>0.05) in each of total TSB, direct bilirubin, indirect bilirubin, total protein, albumin and globulin. The results were based on the determination of unconjugated and conjugated bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT). The serum of people who have non-alcoholic fatty liver disease (NAFLD) may contain elevated levels of AST and ALT. Because bilirubin, albumin, globulin, and total protein do not have any effect on non-alcoholic fatty liver disease (NAFLD), it is reasonable to assume that their levels do not change in people with NAFLD.
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