Effect of Silymarin on the Levels of Thyroid Hormones in Rats Induced Hypothyroidism by Propylthiouracil (PTU)

Abstract

The purpose of this research was to identify any potential protective benefits of silymarin against the thyroid-damaging effects of PTU in male rats, with a focus on antioxidants and thyroid hormones. The following is the breakdown of the six groups comprised of four male rats with an average weight of 190 ± 10 grammes and an age of 90 days: C: For 30 days, 10 male rats in the control group were given distilled water orally. Phase 1: Ten male rats were given PTU (10 mg/kg b.w.) for 30 days. Subject 2: Ten male rats were given silymarin orally at a dosage of 200 mg/kg body weight for a duration of 30 days. T3: 10 male rats were given PTU (10 mg/kg b.w.) and Silymarin (200 mg/kg b.w.) for 30 days. Rats given PTU or silymarin had significantly different thyroid hormone levels, according to the present study. These results show that silymarin may have the ability to regulate thyroid hormone levels in hypothyroidism caused by PTU and imply that there is a complicated interaction between the three factors. To further understand how silymarin works and how long it takes to see results in treating thyroid diseases, more studies are required. Research also shows that silymarin may help with PTU-induced hypothyroidism by increasing GSH levels, decreasing lipid peroxidation, and improving antioxidant enzyme activity. One possible way to combat the oxidative stress that hypothyroidism causes is to take silymarin supplements. To further understand how silymarin works and how long it takes to see results in treating thyroid diseases, more studies are required.