The Effects of Co-Administration of Mangiferin and Artemther-Lumefantrine on Hematological Indices of Plasmodium Berghei Berghei-Infected Swiss Albino Mice

Abstract

Malaria, caused by the parasite Plasmodium falciparum, is prevalent in Nigeria, with an average occurrence rate of 75%. However, it is possible to cure this disease. Chemical-based drugs often induce hematological abnormalities in blood tissues when employed as a treatment approach. This study was conducted due to the need to investigate the effect of co-administration of mangiferin and artemether-lumefantrine on hematological indices of plasmodium berghei-infected Swiss albino mice. Forty-two (42) albino Swiss mice were divided into seven groups, with four groups infected with the blood of highly parasitized P. berghei-infected mice, while three were control groups. Artemether-lumefantrine (AL) was administered as the standard drug, and Mangiferin was used for treating the parasite. Group 1 was the normal control and received normal feed and water ad libitum. Group 2 was infected with P. berghei. Groups 3 and 4 were given 8 mg/kg body weight of artemether-lumefantrine and 410.79 mg/kg of mangiferin, respectively. Groups 5 and 6 were infected with P. berghei and treated with 8 mg/kg body weight of artemether-lumefantrine and 410.79 mg/kg of mangiferin, respectively. Group 7 was infected with P. berghei and treated with artemether-lumefantrine and mangiferin at doses of 8 mg/kg and 410.79 mg/kg body weight, respectively. The animals were sacrificed, and blood was obtained for the estimation of hematological parameters. In the study, giving antimalarial drugs and mangiferin together had a big effect on the production of red blood cells, the decrease in infection, and the clumping of platelets in mice that were infected with P. berghei. The study recommends further research to look into the long-term effects and safety issues of giving mangiferin along with antimalarial drugs in cases of uncomplicated malaria.