Experimental Prophylaxis of Antibiotics in Urological Patients
DOI:
https://doi.org/10.51699/ijhsms.v2i12.2999Keywords:
antimicrobial prophylaxis, antimicrobial drugs, urological surgeryAbstract
This article provides an analysis of the main provisions of the methods of antibacterial prevention before surgery and the basic requirements for antibacterial prevention drugs. Approaches to empirical antibiotic prophylaxis in operations on the kidneys, ureters, bladder, prostate, scrotum organs, as well as reconstructive interventions using a fragment of the intestine are described. A separate review of antibacterial prophylaxis in surgical interventions on the blood vessels of the genitourinary system, penile implantation, testicular prostheses and artificial bladder sphincter, as well as surgical treatment of injuries of the genitourinary tract. Possible infectious and inflammatory complications of the most frequently performed operations in urological practice and ways of their prevention are analyzed in detail. We examined the choice of antibacterial agents depending on the patient's diagnosis, previously used antimicrobial agents and the type of surgical intervention. All the proposed schemes are optimized in three directions: clinical efficacy, economic feasibility, epidemiological safety (prevention of multiplication of strains of microorganisms with multidrug resistance). Particular attention is paid to the choice of a drug for empirical antibiotic prophylaxis in patients with severe concomitant diseases affecting the pharmacokinetics of drugs and reducing the immunological reactivity of the body – renal insufficiency and HIV infection.
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