Relationship between Serum Zinc Level with Immunoglobulin a Plasma Level in Pregnant COVID-19 Patients


  • Izdihar Nsaif Ali Department of Obstetrics and Gynecology, College of Medicine, University of Thi-Qar, Iraq
  • Nadia Saddam Fahad Department of Obstetrics and Gynecology, College of Medicine, University of Thi-Qar, Iraq



Pregnant women, Covid 19, Immunoglobulin A (IgA), Zinc


Background: In maintaining mucosal immunity, Immunoglobulin A (IgA) serves a crucial function. The entry points for infectious pathogens in the respiratory and digestive systems count on IgA as the preeminent immunoglobulin for defense. A proper intake of dietary zinc is pivotal for strong immune competence and resistance to viral infections, ultimately having an impact on IgA levels.

Aim: COVID-19 patients who are pregnant were evaluated to see if there is a correlation between their plasma IgA levels and their serum zinc levels.

Patients and methods: A study was carried out by a private obstetrician clinic between January 2022 and December 2022, with 179 pregnant women split into two groups. 102 women in the first group had acquired COVID-19 at some point throughout their pregnancies. As a control, the second group consisted of 77 pregnant women in good health. IgA and zinc levels were taken during the pregnant women's evaluation in order to compare the two groups and determine the effect of COVID-19 on these parameters. The purpose of this case control study was to ascertain how pregnant women's levels of zinc and IgA were correlated with COVID-19 infection.

Results: Among the cases and controls, variations were found in trimester, parity, family history of COVID-19, presence of COVID-19, and history of vaccination (p<0.05). Analysis of Zinc and IgA levels demonstrated significantly lower levels in pregnant women with COVID-19 compared to those who were healthy (P=0.0001). In both groups, there was a noticeable but weak link between IgA and Zinc levels.

Conclusion: Among pregnant women who had COVID-19, the IgA levels were observed to be lower. Both groups had a weak positive correlation between their Zinc level and IgA level. Protecting a pregnant woman from Covid 19 is important, and research suggests Zinc and IgA can play a role in this protection. Pregnant women have a weakened immune system, making them more vulnerable to illness, so finding ways to boost their immunity is crucial. Zinc has been linked to improved immunity, and some studies indicate that pregnant women who take Zinc supplements can reduce the risk of infection. IgA is an antibody that helps defend mucus membranes, where viruses like Covid 19 enter the body. Studies show that pregnant women who have high levels of IgA are less likely to be affected by Covid 19. By focusing on these key factors, we can help ensure the health and safety of pregnant women and their babies.


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How to Cite

Izdihar Nsaif Ali, & Nadia Saddam Fahad. (2023). Relationship between Serum Zinc Level with Immunoglobulin a Plasma Level in Pregnant COVID-19 Patients. INTERNATIONAL JOURNAL OF HEALTH SYSTEMS AND MEDICAL SCIENCES, 2(11), 307–313.