Immune-Mediated Inflammation of Coronary Heart Disease in Patients with Psycho-Emotional Disorders
DOI:
https://doi.org/10.51699/ijhsms.v1i4.299Keywords:
coronary heart disease, hypercholesterolemia, atherosclerosis, psych emotional statusAbstract
Coronary heart disease (CHD) involves the development of severe coronary atherosclerosis and subsequent decrease in blood flow to the heart. Traditional risk factors such as smoking, diabetes, hypercholesterolemia and systemic hypertension are involved in the pathogenesis of CHD. However, 40-60% of cases of predisposition to CHD are hereditary, so it is generally believed that CHD is the result of both genetic predisposition and traditional risk factors [1,4,6]. In the Framingham Heart Study, a family history of CHD was defined as heart disease in immediate family members under age 60 in men or age 65 in women and was a powerful predictor of CHD [2,7,10]. Approximately one-third of patients with CHD have a family history of CHD, and individuals with a family history of CHD are approximately 1.5 times more likely to have a lifetime history of CHD than individuals without a family history [3,5,7].
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A. Abdi-Ali, A. Shaheen, D. Southern, et al. Relation between family history of premature coronary artery disease and the risk of death in patients with coronary artery disease Am J Cardiol, 117 (3) (2016), pp. 353-358
A. Singh, A. Gupta, B.L. Collins, et al. Familial hypercholesterolemia among young adults with myocardial infarction J Am Coll Cardiol, 73 (19) (2019), pp. 2439-2450
A.B. Jørgensen, R. Frikke-Schmidt, B.G. Nordestgaard, A. Tybjærg-Hansen Loss-of-function mutations in APOC3 and risk of ischemic vascular disease N Engl J Med, 371 (1) (2014), pp. 32-41
A.V. Khera, S. Kathiresan Genetics of coronary artery disease: discovery, biology and clinical translation Nat Rev Genet, 18 (6) (2017), pp. 331-344
C.A. Emdin, A.V. Khera, D. Klarin, et al. Phenotypic consequences of a genetic predisposition to enhanced nitric oxide signaling Circulation, 137 (3) (2018), pp. 222-232
C.Y. Cheng, K. Yamashiro, L.J. Chen, et al. New loci and coding variants confer risk for age-related macular degeneration in East Asians Nat Commun, 6 (2015), p. 6063
D. Klarin, Q.M. Zhu, C.A. Emdin, et al. Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease Nat Genet, 49 (9) (2017), pp. 1392-1397
F.B. Ortega, C.J. Lavie, S.N. Blair Obesity and cardiovascular disease Circ Res, 118 (11) (2016), pp. 1752-1770
G.B. Ehret, T. Ferreira, D.I. Chasman, et al. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals Nat Genet, 48 (10) (2016), pp. 1171-1184
H. Pang, Z. Zong, L. Hao, Q. Cao ABO blood group influences risk of venous thromboembolism and myocardial infarction J Thromb Thrombolysis, 50 (2) (2020), pp. 430-438
H. Schunkert Family or SNPs: what counts for hereditary risk of coronary artery disease Eur Heart J, 37 (6) (2016), pp. 568-571
H. Wang, Z. Liu, J. Shao, et al. Immune and inflammation in acute coronary syndrome: molecular mechanisms and therapeutic implications J Immunol Res, 2020 (2020), p. 4904217
I. Brænne, M. Kleinecke, B. Reiz, et al. Systematic analysis of variants related to familial hypercholesterolemia in families with premature myocardial infarction Eur J Hum Genet, 24 (2) (2016), pp. 191-197
I.J. Kullo, H. Jouni, E.E. Austin, et al. Incorporating a genetic risk score into coronary heart disease risk estimates: effect on low-density lipoprotein cholesterol levels (the MI-GENES clinical trial) Circulation, 133 (12) (2016), pp. 1181-1188
J.P. Collet, M. Zeitouni, N. Procopi, et al. Long-term evolution of premature coronary artery disease J Am Coll Cardiol, 74 (15) (2019), pp. 1868-1878
L. Chen, H. Qian, Z. Luo, et al. PHACTR1 gene polymorphism with the risk of coronary artery disease in Chinese Han population Postgrad Med J, 95 (1120) (2019), pp. 67-71
M. Nikpay, A. Goel, H.H. Won, et al.A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease Nat Genet, 47 (10) (2015), pp. 1121-1130
M.S. Sabatine, R.P. Giugliano, A.C. Keech, et al. Evolocumab and clinical outcomes in patients with cardiovascular disease N Engl J Med, 376 (18) (2017), pp. 1713-1722
Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, N.O. Stitziel, K.E. Stirrups, et al. Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease N Engl J Med, 374 (12) (2016), pp. 1134-1144
Myocardial Infarction Genetics Consortium Investigators, N.O. Stitziel, H.H. Won, et al. Inactivating mutations in NPC1L1 and protection from coronary heart disease N Engl J Med, 371 (22) (2014), pp. 2072-2082
O. Bilen, Y. Pokharel, C.M. Ballantyne Genetic testing in hyperlipidemia Cardiol Clin, 33 (2) (2015), pp. 267-275
P. Nioi, A. Sigurdsson, G. Thorleifsson, et al. Variant ASGR1 associated with a reduced risk of coronary artery disease N Engl J Med, 374 (22) (2016), pp. 2131-2141
P. van der Harst, N. Verweij Identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease
P.M. Ridker From CANTOS to CIRT to COLCOT to clinic: will all atherosclerosis patients soon Be treated with combination lipid-lowering and inflammation-inhibiting agents Circulation, 141 (10) (2020), pp. 787-789
P.M. Ridker, B.M. Everett, T. Thuren, et al.Antiinflammatory therapy with canakinumab for atherosclerotic disease
R. Roberts Genetic risk stratification: tipping point for global primary prevention of coronary artery disease Circulation, 137 (24) (2018), pp. 2554-2556
R.M. Gupta, J. Hadaya, A. Trehan, et al. A genetic variant associated with five vascular diseases is a distal regulator of endothelin-1 gene expression
S. Sandler, L. Alfino, M. Saleem The importance of preventative medicine in conjunction with modern day genetic studies Genes Dis, 5 (2) (2018), pp. 107-111
S. Thériault, R. Lali, M. Chong, J.L. Velianou, M.K. Natarajan, G. Paré Polygenic contribution in individuals with early-onset coronary artery disease
S.D. Kumbhalkar, V.V. Bisne Clinical and angiographic profile of young patients with ischemic heart disease: a central India study J Clin Prev Cardiol, 8 (2019), pp. 6-12
T. Li, L. Ding, Y. Wang, O. Yang, S. Wang, J. Kong Genetic deficiency of Phactr1 promotes atherosclerosis development via facilitating M1 macrophage polarization and foam cell formation Clin Sci (Lond)., 134 (17) (2020), pp. 2353-2368
T.L. Assimes, D.M. Herrington Genetic risk scores in premature coronary artery disease: still only one piece of the prevention puzzle Circ Genom Precis Med, 11 (1) (2018), Article e002006
T.L. Assimes, R. Roberts Genetics: implications for prevention and management of coronary artery disease J Am Coll Cardiol, 68 (25) (2016), pp. 2797-2818
Y. Abramowitz, A. Roth, G. Keren, et al. Whole-exome sequencing in individuals with multiple cardiovascular risk factors and normal coronary arteries Coron Artery Dis, 27 (4) (2016), pp. 257-266
Y. Okuyama, N. Hirawa, M. Fujita, et al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice Hypertens Res, 41 (2) (2018), pp. 80-87
