Therapeutic Effect of Chitosan Nanoparticles and Amikacin in Treatment of Experimentally Escherichia bacteria isolated from diarrheal cases
Keywords:Chitosan nanoparticles, amikacin
Background: The application of nanotechnology in medicine, especially in drug delivery, will rapidly spread. Many substances are currently being investigated for drug delivery in order to the treatment of various diseases. The present study aimed to assess the effect of Chitosan Nanoparticles and Amikacin in Treatment of experimentally Escherichia coli bacteria isolated from diarrheal cases as well as evaluate the efficacy of loading Amikacin on chitosan nanoparticles.
Methods: This study was carried out at medicine Department, college of Medicine, Wasit University and lab tore of Al-Batool Hospital in Wasit Governorate from February 2022 to February 2023. The study was conducted on 60 children (males and females) under the age of 5 years who were diagnosed with Escherichia coli bacterial infection from cases of diarrhea for patients in Al-Batool Hospital in the city of Wasit.
All samples were grouped into three groups: group A include E. coli infected individual treated with Amikacin alone, group B include E. coli infected individual treated with Chitosan nanoparticles alone and group C include E. coli infected individual treated with Chitosan nanoparticles and Amikacin.
Results: The highest percentages of reduction inhibition were in group that received mixed Chitosan nanoparticles and Amikacin treatment (67.34). Lower percentages of reduction were recorded for TRI only treated group (58.15%). where the incidence of E. coli in males was higher than that of females (61.51%) and (60.33%) respectively.
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