Comparison of Labetalol and Methyldopa's Effectiveness in Treating Hypertension in Pregnancy


  • Karrar Abed Almonem Hadi Maki Alkhafagy F.I.C.M.S. Anaesthesia and Intensive Care Specialist, Al Hilla General Teaching Hospital
  • Mahir Hussein Hasan AlSaadawi F.I.C.M.S. Anaesthesia and Intensive Care Specialist, Imam Sadiq Teaching Hospital
  • Mohammed Ali Ibrahim Kareem Al-jibawi F.I.C.M.S. Anaesthesia and Intensive Care Specialist, Al Hilla General Teaching Hospital



Background: A significant number of the population lacks access to healthcare in an Iraq-like country, despite the country's constant growth and development in the healthcare sector, the rate of fatal maternal deaths is still high.

The most common medical issue during pregnancy is high blood pressure. On a global scale, 6-8% of pregnancies are said to have been complicated by high blood pressure. Antihypertensive treatments are frequently utilized to lower the blood pressure in order to prevent the pressure from increasing to a level that would negatively affect the mother or baby. Using anti-hypertensive drugs reduces the likelihood of developing severe high blood pressure by half. Therefore, the goals of this study were to determine how well labetalol and methyldopa manage blood pressure in PIH patients and to look into the effects of pregnancy and the perinatal period.

Methods: 180 PIH patients were split into two groups at random. Following random assignment, group A was given 250 mg of methyldopa every other day, and group B was given 100 mg of labetalol. The formula employed to calculate the average pressure in the arteries (MAP) was 2 + 3.5 diastolic BP /6. Patients were monitored for signs of hypotension every six hours. Every day, the MAPs of the two groups were calculated to assess the effectiveness of a particular medicine. Observations regarding the drop in blood pressure with Labetalol/ Methyldopa were documented. the average amount of medication necessary to regulate blood pressure, the beginning of labor--induced or spontaneous--Bishop's initial score during the onset of labor's effects on drugs.

Results: The MAP of patients on labetalol decreased significantly. The average time required in group A to control B.P. was Group B had an average sleep duration of 36.97 hours, compared to group A's 42.22 hours. In the present study, group A's average Bishop score at induction was 8.27, but group B's was 9.33. The statistical analysis revealed a significant difference between the two groups, with p<0.05. In group B, 23 patients, or 48.94 percent of the patients, had spontaneous labor experience; in group A, 33.33 percent of the patients experienced spontaneous labor.

Final thoughts: Because of its effective hypotensive effect and lack of negative side effects on either the mother or the baby, labatalol is safe during childbirth.


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How to Cite

Maki Alkhafagy, K. A. A. H. ., AlSaadawi, M. H. H. ., & Al-jibawi, M. A. I. K. . (2023). Comparison of Labetalol and Methyldopa’s Effectiveness in Treating Hypertension in Pregnancy. INTERNATIONAL JOURNAL OF HEALTH SYSTEMS AND MEDICAL SCIENCES, 2(11), 63–70.