Synthesis, Characterization and Antibacterial Activity of Carboxylated Polyvinylpyrrolidone Conjugation with Tranexamic Acid (TXA)
DOI:
https://doi.org/10.51699/ijhsms.v2i10.2734Keywords:
tranexamic acid (TXA), PVP, antfibrinolyticAbstract
Polymer conjugation with biologically active components has become a very attractive system as it could improve the efficacy of some drugs. This study aims to prepare and formulate a topical polymer conjugate with biologically active components for a therapy of bleeding using tranexamic acid as a drug model and study the antibacterial activity of the resultant products.
The polymeric matrix involved carboxylated polyvinylpyrrolidone. Hence, carboxylated polyvinylpyrrolidone was bonding with tranexamic acid by an amide bond (P1), resulting in a product complex with iodine (P2).
In order to determine the amount of medication present in these derivatives, FTIR, DSC, and 1HNMR characterization techniques were utilized. The antibacterial potential of the prepared samples (P1, P2) with the use of PVP iodine as a control was studied against different amounts of Grammeme's negative and Grammeme's positive bacteria, including Pseudomonas aeruginosa, E. coli, S. aureus, and K. pneumoniae. There were four different strains of bacteria tested. When bacteria like E. coli and S. aureus were used, the results showed that P1 and P2 were more effective at killing bacteria than PVP iodine.
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