The Effectiveness of Methotrexate in the Treatment of Non-Infectious Uveitis
DOI:
https://doi.org/10.51699/ijhsms.v2i5.1791Keywords:
uveitis, immunosuppression, methotrexateAbstract
Non-infectious uveitis is a heterogeneous group of autoimmune diseases, in which, as a rule, it is not possible to detect a specific infectious agent that triggers the inflammatory process in the vascular membrane of the eye. In the etiopathogenesis of non-infectious uveitis, the leading role of immune mechanisms is assumed, which can be initiated by various exogenous (common infections, toxins, medications, eyeball injury, etc.) and endogenous (complement, etc.) stimuli.
In uveitis of autoimmune pathology, immunosuppression affects the uveal membrane of the eye, as well as systemic manifestations of the disease. The appointment of immunosuppressive therapy of uveitis is indicated in the presence of systemic manifestations of the disease. The widespread use of glucocorticoids leads to many side effects and does not allow to control the course of uveitis, which is explained by frequent relapses of the disease, which lead to the development of side effects.
In patients with complicated course of uveitis and with the threat of vision loss, the appointment of metatrexate as immunosuppressive therapy is indicated.
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