Some Aspects of Hemostasis Disorders in Newborns with Perinatal Encephalopathy

Abstract

According to WHO, 10% of newborns worldwide have neurological disorders in the form of encephalopathy and brain dysfunctions, caused by hypoxic-ischemic damage to the brain of the fetus and newborn. It is known that cerebral circulation disorders in newborns are accompanied by the development of hemorrhagic and thrombohemorrhagic complications largely due to the peculiarities of the hemostasis system in the early postnatal period. The causes of these changes in the hemostasis system, as well as their role in the development of the disease, have not been fully studied. Purpose of the study: To study the state of the coagulation system in newborns with perinatal encephalopathy and to develop criteria for the severity of encephalopathy based on coagulogram data. Study materials and methods: the results of the study of 110 newborns with perinatal encephalus are presented. Study materials and methods: the results of a study of 110 newborns with moderate to severe perinatal encephalopathy are presented. Methods of laboratory analysis of hematology parameters, blood coagulation system parameters were applied: bleeding time, fibrin, fibrinogen, thrombotest, prothrombin time, prothrombin index, activated partial thromboplastin time. Results and discussion: In children with moderate perinatal encephalopathy in the early and late neonatal period, changes in the hemostasis system consist of prolonged bleeding time (4,0-5,1/min at a rate of 3,3-3,4/min) and increased fibrinogen levels (3,190-4,43 at a rate of 1,25-3,0 g/L) above the age limit. In children with severe perinatal encephalopathy, there is increased clotting according to APTT (3,35-37,1 s.), Above the age norm; bleeding time is prolonged (4,1-3,6 with a norm of 3,3-3,4 minutes); increased values of prothrombin time indicators and fibrinogen: 20,4-26,7 s at a rate of 15-18 s.; 3,88-4,79 g/l at a rate of 1,25-3,0 g/l.