Senescence of Cell

Authors

  • Samah Ibrahem Ahmed

DOI:

https://doi.org/10.51699/ijbea.v2i7.2268

Abstract

Cellular senescence is the cessation of cell division in multicellular organisms' somatic cells. It causes the depletion of energy reserves necessary for cell division. The inability to proliferate prevents senescent cells from synthesizing new DNA and sustaining growth (Cotter MA et al., 2007; Smith OM, 1996; Smith JR, Pereira-).

References

AdamsSP, Hartman TP, Lim KY, Chase MW, Bennett MD, Leitch IJ, Leitch AR. Loss and recovery of Arabidopsis-type telomere repeat sequences "-(TTTAGGG)(n)-" in the evolution of a major radiation of flowering plants. Proc R Soc Land B Biol Sci. 268:1541-1546, 2001.

Ben-Porath I, Weinberg RA. When cells get stressed: an integrative view of cellular senescence. J Clin Invest. 2004; 113:8-13.

Berube NG, Smith JR, Pereira-Smith OM. The genetics of cellular senescence. Am J Hum Genet. 1998; 62:1015-9.

Braig M, Lee S, Loddenkemper C, Rudolph C, Peters AH, Schlegelberger B, et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature. 2005; 436:660-5.

Campisi J. Cancer and ageing: rival demons? Nat Rev Cancer. 2003; 3:339-49.

Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 2001; 11:27-31.

Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell. 2005; 120:513-22.

Campisi, J. (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors, Cell, 120(4), 513-22.

Chayama K, Yasui W, Tahara E. Expression of telomeric repeat binding factor' and 2 and TRF¹ -interacting nuclear protein 2 in human gastric carcinomas. Int J Oncol 19:507-512, 2001a.

Chen HJ, Cho CL, Liang CL, Chen L, Chang HW, Lu K, Lee TC. Differential telomerase expression and telomere length in primary intracranial tumors. Chang Gung Med J 24:352-360, 2001.

Chen JH, Hales CN, Ozanne SE. DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res. 2007; 35:7417-28.

Collado, M., Blasco, M., and Serrano, M.( ). Cellular senescence in cancer and aging. Cell 130, 223-233.

Cong YS, Wright WE, Shay JW. Human telomerase and its regulation. Microbiol Mol Biol Rev 66:407-425, 2002.

Cotter MA, Florell SR, Leachman SA, Grossman D. Absence of senescence-associated B,-galactosidase activity in human melanocytic nevi in vivo. J Invest Dermatol. 2007; 127:2496- 71.

Cristofalo, V.J., Allen, R.G., Pignolo, R.J. et al. (1998) Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation, Proceedings of the National Academy of Sciences of the USA,95(18), 10614-19.

Cuervo AM (2006). Autophagy in neurons: it is not all about food. Trends Mol Med 12:641-464.

Cuervo AM, Bergamini E, Brunk UT, et al. (2005). Autophagy and aging: the importance of maintaining "clean" cells. Autophagy 1:131-140.

Cunado N, Sanchez-Moran E, Barrios J, Santos JL. Searching for telomeric sequences in two Allium species. Genome 44:640-643, 2001.

d'Adda di Fagagna, F., Reaper, P., Clay-Farrace, L., Fiegler, H., Carr, P., Von Zglinicki, T., Saretzki, G., Carter, N., and Jackson, S. (). A DNA damage checkpoint response in telomere-initiated senescence. Nature. 426, 194-198.

de Lange T. Telomere capping -one strand fits all. Science 292:1075-1076, 2001.

de Magalhaes JP. From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing. Exp Cell Res. 2004; 300: 1-10.

Dimri, G.P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E.E., Linskens, M., Rubelj, I., Pereira-Smith, O., etal. (1995). A biomarker that identifies senescent human cells in culture and in Aging skin in vivo. Proc. Natl. Acad. Sci. USA. 92, 93623-9367.

Donati A, Ventruti A, Cavallini G, et al. (2008). In vivo effect of an antilipolytic drug (dimethylpyrazole) on autophagic proteolysis and autophagy-related gene expression in ratliver. Biochem Biophys Res Commun 366:786-792.

Effros RB (1998) Replicative senescence in the immune system: impact of the Hayfiick limit on T-cell function in the elderly. Am J Hum Genet It: 62:000- 000 (in this issue).

Forstemann K, Lingner J. Molecular basis for telomere repeat divergence in budding yeast. Mol cell Biol21:7277-7286, 2001.

Gire, V., Roux, P., Wynford-Thomas, D., Brondello, J., and Dulic, V. (2004) DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J. 23, 2554-2563.

Hayfiick L (1965)The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37:614-636.

Herbig, U., Jobling, W., Chen, B., Chen, D., and Sedivy, J. (2004). Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and, but not p21 (CIP1), but not p16(INK4) mol cell 14, 501-513.

Hipkiss AR (2006). Accumulation of altered proteins and ageing: causes and effects. Exp Gerontol 41:464-473.

inogenesi.10 Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, et al. BRAFE"600 associated senescence-like cell cycle arrest.

Itahana K, Campisi J, Dimri GP. Mechanisms of cellular senescence in human and mouse cells. Biogerontology.2004; 5:1-10.

Itahana K, Dirnri G, Campisi J. Regulation of cellular senescence by p53 Eur J Biochem. 2001; 268:2784-91.

Itahana, K., Campisi, J., and Dimri, G.P. (2004)Mechanisms of cellular senescence in human and mouse cells. Biogerontology 5:1-10.

Jackson JG, Pereira-Smith OM. p53 preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts. Cancer Res. 2006; 66:8356-60.

JVLedtano EE, et al p Hi)-A-bi&mafker that idcnttfies- senescent Jmman cefe-ift-etritttrc and in aging skin in vivo.

Kiffin R, Bandyopadhyay U, and Cuervo A (2006). Oxidative stress and autophagy. Antioxid Redox Signal 8:152-162.

Kipling, D., Davis, T., Ostler, E.L. et al. (2004) What can progeroid syndromes tell us about human aging?, Science, 305(5689), 1426-31.

Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci USA. 2001; 98:12072-7.

Levine B (2007). Cell biology: autophagy and cancer. Nature 446:745-747.

Levine B and Deretic V (2007). Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol7:767-777.

Li B, Oestreich S, de Lange T. Identification of human implications for telomere evolution. Cell 101:471-483, 2000.

Downloads

Published

2023-07-26

How to Cite

Ahmed, S. I. . (2023). Senescence of Cell. International Journal of Biological Engineering and Agriculture, 2(7), 22–36. https://doi.org/10.51699/ijbea.v2i7.2268

Issue

Section

Articles